Bone metabolism is a term describing the constant production and degradation of bone tissue, necessary for its maintenance and repair. The production and degradation of bone are the result of the activity of osteoblasts and osteoclasts, respectively.
Bone metabolism is a continual cycle of bone growth and resorption that is carefully orchestrated by the dynamic relationship between osteoclasts, osteoblasts and an array of hormonal and regulatory influences. The relative levels of these signaling molecules dictate whether healthy, balanced bone metabolism ensues. Disturbances to this delicate equilibrium where resorption is greater than growth can weaken the skeletal architecture and put one at risk for the development of chronic and debilitating diseases such as Osteoporosis.