INTRODUCTION
LARENTINE 5MG contain memantine which belongs to a group of medicine called NMDA receptor antagonists. It is used for the treatment of patients with moderate to severe Alzheimer’s disease. Alzheimer’s disease is a progressive disease that destroy memory and mental functions. Memory loss in Alzheimer’s disease is due to disturbance of message signals in the brain. The brain contains N-methyl-D-aspartate (NMDA)-receptor that are involved in transmitting nerve signals important in learning and memory. This medicine acts on these NMDA-receptors improving the transmission of nerve signals and the memory.
Glutamate is a chemical that helps to send messages between nerve cells in the brain. In Alzheimer’s disease nerve cells are damaged resulting in the production of too much of glutamate. This causes more damage to the nerve cells. Memantine protects nerve cells by blocking the effects of excess glutamate without disturbing the normal transmission of nerve signals.
The common side effects are headache, sleepiness, constipation, elevated liver function tests, dizziness, balance disorders, shortness of breath, high blood pressure, hypersensitivity. This medicine is strictly not recommended for use in children and adolescents under 18 years. Before taking this medicine tell your doctor if you have ever had kidney disease, heart disease, liver problems. Pregnant and breastfeeding women should consult their doctor before taking this medicine.
USES OF LARENTINE 5MG
- Treat patients with moderate to severe Alzheimer’s disease
HOW LARENTINE 5MG WORKS
Glutamate is a chemical that helps to send messages between nerve cells in the brain. In Alzheimer’s disease nerve cells are damaged resulting in the production of too much of glutamate. This causes more damage to the nerve cells. Memantine protects nerve cells by blocking the effects of excess glutamate without disturbing the normal transmission of nerve signals.
DIRECTIONS FOR USE
Always take LARENTINE 5MG exactly as your doctor has told you. This medicine must be taken with or without food. Try to take at the same time each day. It should be swallowed whole with water. Do not crush or chew the medicine. The recommended dose is one tablet once a day.
SIDE EFFECTS OF LARENTINE 5MG
COMMON
- Headache
- Sleepiness
- Constipation
- Elevated liver function tests
- Dizziness
- Balance disorders
- Shortness of breath
- High blood pressure
- Hypersensitivity
HOW TO MANAGE SIDE EFFECTS
Headache:
Apply hot or cold-water bag on your head. Take rest in a quiet and dark room. Drink tea or coffee.
Sleepiness:
Get up and move around to feel awake. Take a nap to take the edge off the sleepiness. Give your eyes a break to avoid weakness.
Constipation:
Take fibre rich foods such as fresh fruit, vegetables and cereals, and drink plenty of water. Exercise more regularly.
Dizziness:
Get up and move around to feel awake, take small naps to edge off the sleepiness. Give your eyes a break to avoid fatigue and eat a healthy food to boost energy.
WARNING & PRECAUTIONS
PREGNANCY
LARENTINE 5MG is not recommended for use in pregnant women unless necessary. Discuss the risks and benefits with your doctor.
BREASTFEEDING
LARENTINE 5MG is not recommended for use in breastfeeding women unless necessary. Discuss the risks and benefits with your doctor.
DRIVING AND USING MACHINES
Your doctor will tell you whether your illness allows you to drive and to use machines safely. Also LARENTINE 5MG may change your reactivity, making driving or operating machinery inappropriate.
ALCOHOL
Consumption of alcohol is not recommended during treatment with LARENTINE 5MG.
KIDNEY
LARENTINE 5MG should be used with caution in patients suffering from active kidney diseases. Consult your doctor for advice.
LIVER
LARENTINE 5MG should be used with caution in patients suffering from liver function impairment or active liver diseases. Consult your doctor for advice.
ALLERGY
Do not take LARENTINE 5MG if you are allergic (hypersensitive) to memantine or any other ingredients in this medicine.
HEART DISEASE
LARENTINE 5MG should be used with caution in patients suffering from active heart diseases. Consult your doctor for advice.
OTHERS
Tell your doctor if you have or had conditions such as,
- Have a history of epileptic seizures
- Suffering from high blood pressure
- Severe infections of the urinary tract
INTERACTIONS
Talk to your doctor if you are taking,
- Amantadine (used to treat Parkinson’s disease)
- Ketamine (used as an anaesthetic)
- Dextromethorphan (used to treat cough)
- Dantrolene, baclofen
- Cimetidine, ranitidine, procainamide, quinidine, quinine, nicotine
- Hydrochlorothiazide
- Anticholinergics (used to treat movement disorder or intestinal cramps)
- Anticonvulsants (used to prevent and relieve seizures)
- Barbiturates (used to induce sleep)
- Dopaminergic agonists such as L-dopa, bromocriptine
- Neuroleptics (used to treat mental disorders)
- Oral anticoagulants
SYNOPSIS
| Drug | : | Memantine hydrochloride |
| Pharmacological Category | : | NMDA receptor antagonists |
| Therapeutic Indication | : | Alzheimer’s disease |
| Dosage Forms | : | Tablet, Capsule |
MORE INFORMATION
Store below 20-25°C and keep out of reach of children.
FAQs ABOUT LARENTINE 5MG
Can I just stop taking LARENTINE 5MG?
No, you should not be stopped even if you feel well. This medicine only helps to control the symptoms of Alzheimer’s disease but does not cure it. If you need to stop this medicine, consult your doctor.
Does LARENTINE 5MG have abuse potential?
No, it does not have abuse potential.
Can LARENTINE 5MG cause headache?
Yes, this medicine may cause headache in some individuals. Apply hot or cold-water bag on your head. Take rest in a quiet and dark room. Drink tea or coffee.
