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Enzalunix 40mg, Enzalutamide Tablets
Home Cancer Enzalunix 40mg, Enzalutamide Tablets
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Enzalunix 40mg, Enzalutamide Tablets

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Category: Cancer Tag: prostate cancer
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Description

Enzalunix 40mg, Enzalutamide Tablets

Enzalunix 40mg is a brand formulation of Enzalutamide, a potent oral medication used in the management of prostate cancer. Belonging to the class of androgen receptor inhibitors, it has transformed the treatment landscape for patients with advanced and metastatic castration-resistant prostate cancer (mCRPC) and certain cases of metastatic hormone-sensitive prostate cancer (mHSPC). Unlike older therapies that mainly focus on reducing androgen levels, Enzalutamide directly blocks androgen receptor signaling, thereby inhibiting the growth and spread of prostate cancer cells.

This medicine is generally prescribed under strict medical supervision and is a vital part of modern oncological therapy, especially for patients whose disease progresses despite standard hormonal therapy.

What is Enzalunix 40mg?

Enzalunix 40mg contains Enzalutamide as its active ingredient. It is a selective androgen receptor inhibitor that is taken orally and is nonsteroidal. It is available in tablet form and usually prescribed as part of long-term prostate cancer management.

Key details:

  • Drug Class: Androgen Receptor Inhibitor
  • Strength: 40mg per tablet
  • Route of Administration: Oral
  • Indication: Treatment of advanced prostate cancer (metastatic or resistant to other hormone therapy)

How it Works / Mechanism of Action

Prostate cancer growth is largely driven by male hormones called androgens (mainly testosterone and dihydrotestosterone). These hormones act through androgen receptors to stimulate cancer cell survival and proliferation.

Enzalutamide works through multiple mechanisms:

  • Prevents androgen binding: It competitively inhibits androgens from binding to androgen receptors.
  • Blocks receptor activation: It prevents the androgen receptor from being activated, even if androgens are present.
  • Stops nuclear translocation: Normally, activated androgen receptors move into the cell nucleus and regulate gene transcription; Enzalutamide blocks this process.

Inhibits cancer cell growth signals: By preventing receptor-DNA binding, it suppresses growth-promoting genes.

Thus, Enzalutamide provides a comprehensive blockade of androgen receptor signaling, offering superior control over prostate cancer compared to traditional hormonal therapies.

How to Use / Indications

Enzalunix 40mg is indicated for:

  • Metastatic Castration-Resistant Prostate Cancer (mCRPC): Patients whose cancer continues to progress despite surgical or medical castration.
  • Metastatic Hormone-Sensitive Prostate Cancer (mHSPC): In combination with androgen deprivation therapy (ADT).
  • Non-Metastatic Castration-Resistant Prostate Cancer (nmCRPC): For patients at high risk of developing metastasis.
  • Doctors may also consider Enzalutamide in patients who have previously received chemotherapy with docetaxel or other androgen pathway inhibitors.

How to Take / Dosage

  • Standard Dose: 160 mg once daily (i.e., 4 tablets of Enzalunix 40mg).
  • Tablets should be taken orally with or without food.
  • Swallow whole with water; do not crush or chew.
  • Continue androgen deprivation therapy (e.g., LHRH analog) while taking Enzalutamide unless the patient has undergone surgical castration.

Other Dosage & Adjustments

  • Renal Impairment: Usually no dose adjustment is required for mild-to-moderate renal impairment. Severe impairment may need monitoring.
  • Hepatic Impairment: Mild or moderate impairment may not require adjustment, but severe cases must be monitored.
  • Elderly Patients: No special adjustment unless comorbidities require it.
  • Missed Dose: If a dose is missed, take it as soon as remembered. If it is close to the next dose, skip and resume a normal schedule. Do not double dose.

Side Effects

Like all potent anticancer drugs, Enzalunix 40mg has possible side effects. These vary from mild to severe and may require medical management.

Common side effects:

  • Fatigue and weakness
  • Hot flashes
  • Hypertension
  • Back pain, joint pain
  • Headache and dizziness
  • Diarrhea or constipation

Serious side effects:

  • Seizures: Rare but significant risk.
  • Falls and fractures: As a result of weak muscles and lightheadedness.
  • Cardiac disorders: Risk of heart problems or worsening hypertension.
  • Cognitive effects: Memory impairment, confusion.
  • Hepatic dysfunction: Elevated liver enzymes.
  • Immediate medical help should be sought if seizures, chest pain, jaundice, or severe allergic reactions occur.

Storage

  • Store below 30°C in a dry place.
  • Keep away from direct light and moisture.
  • Keep out of reach of children and pets.
  • Do not use after an expiry date mentioned on the package.

Benefits

  • Significant therapeutic advantages are provided by Enzalunix 40mg in the treatment of prostate cancer:
  • Improved overall survival in patients with mCRPC.
  • Delays disease progression in both metastatic and non-metastatic settings.
  • Better quality of life by reducing tumor-related symptoms.
  • Oral administration makes it convenient compared to intravenous therapies.
  • Can be used before or after chemotherapy, giving flexibility in treatment planning.

Prescription

Enzalunix 40mg is a prescription-only medicine (POM). It must be prescribed by an oncologist or urologist experienced in managing prostate cancer. Self-medication is strongly discouraged due to risks of seizures, drug interactions, and serious side effects.

Drug Interactions

Enzalutamide can interact with several medications due to its effect on liver enzymes (CYP450 system).

Major interactions include:

  • Warfarin & anticoagulants – risk of reduced effectiveness.
  • CYP2C8 inhibitors (e.g., gemfibrozil) – may increase Enzalutamide levels.
  • CYP3A4 inducers (e.g., rifampin, carbamazepine, phenytoin) – may decrease its effectiveness.
  • Other seizure-inducing drugs – increase seizure risk.
  • Certain statins, antifungals, and antivirals – possible altered drug metabolism.
  • Always inform the doctor about all medications, herbal supplements, or over-the-counter drugs being use.

FAQs

Can Enzalunix 40mg cure prostate cancer?

No, it cannot cure prostate cancer, but it can control disease progression and improve survival outcomes.

Can Enzalutamide be take with food?

Yes, it can be take with or without food.

Is it safe for elderly patients?

Yes, but monitoring is require as elderly patients are more prone to falls, dizziness, and cognitive impairment.

Conclusion

A novel oral treatment for advanced prostate cancer, Enzalunix 40mg (Enzalutamide Tablets) provides complete androgen receptor inhibition. It is particularly valuable for patients whose cancer progresses despite castration or hormone therapy. While highly effective in prolonging survival and improving quality of life, it must be used under expert supervision due to potential side effects like seizures, hypertension, and liver toxicity.

With its convenient oral administration and proven clinical benefits, Enzalunix 40mg represents a cornerstone in modern prostate cancer therapy. However, careful monitoring, correct dosage, and awareness of drug interactions are essential to maximize benefits and minimize risks.

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