JOLAVI contains Midodrine which belongs to the group of medicines called alpha-1 adrenergic agonist. It is used to treat low blood pressure in adults when other treatments have not worked. Symptoms of low blood pressure includes dizziness or lightheadedness, fainting, blurred vision, nausea, fatigue or lack of concentration.
Midodrine is a prodrug of deglymidodrine. It increases your blood pressure by enhancing smooth muscle tone leading to vasoconstriction of blood vessels. Prior to the treatment, your doctor would check your kidney function and blood pressure to access your condition. During the treatment, regular monitoring of your blood pressure while you are lying down or standing up will be required.
The most common side effects of taking this medicine are high blood pressure, chest pain, increased heartbeat, shortness of breath, headache and blurred vision. Contact your doctor immediately, if you experience any of these symptoms. It is always important that you do not take this medicine late in the evening. Try to take your last daily dose at least 4 hours before bedtime. Before taking this medicine, inform your doctor if you have any other heart disease or kidney disease. This medicine is not recommended for use in pregnant or breastfeeding women and in children less than 18 years of age.
USES OF JOLAVI
- Treats low blood pressure
HOW JOLAVI WORKS
Midodrine is converted to its active metabolite, deglymidodrine which binds to and activates alpha1-adrenergic receptors present in the blood vessels, which enhances smooth muscle tone, leading to peripheral vasoconstriction and elevation of blood pressure.
DIRECTIONS FOR USE
Take this medicine as directed by your physician. Do not crush or chew the medicine. Your doctor will decide the correct dose for you depending upon your condition. Continue to take this medicine, as long as your doctor tells you to do so, to obtain better results.
SIDE EFFECTS OF JOLAVI
- Itching of scalp
- Difficulty in urination
- Increased blood pressure when lying down
- Nausea (feeling sick)
- Tingling and itching
- Flushing, rash, chills
- Inflammation of lining inside mouth
- Increased heartbeat
HOW TO MANAGE SIDE EFFECTS
Feeling sick (nausea):
Try taking this medicine with, or just after meal. Stick to simple meals. Do not eat rich or spicy food.
Avoid hot showers or baths because hot water can irritate the scalp. Do not rub or scratch the affected area.
Rest and drink plenty of fluids. Do not drink too much alcohol.
WARNING & PRECAUTIONS
JOLAVI is not recommended for use in pregnant women unless necessary. Discuss the risks and benefits with your doctor.
JOLAVI is not recommended for use in breastfeeding women unless necessary. Discuss the risks and benefits with your doctor.
DRIVING AND USING MACHINES
Do not drive or operate machinery while taking this medicine, since it may cause dizziness or light headedness.
Avoid consumption of alcohol while taking this medicine.
Do not take JOLAVI if you have severe kidney disease. Consult your doctor for advice.
Do not take this medicine if you are allergic (hypersensitive) to midodrine.
Do not take JOLAVI if you have heart diseases like high blood pressure, abnormal heartbeat, heart attack or angina. Consult your doctor for advice.
Do not take this medicine, if you:
- Have glaucoma (increased pressure in the eye), poor vision due to diabetes, an over-active thyroid gland, pheochromocytoma (tumour near the kidney) or an enlarged prostate
Talk to your doctor, if you are taking,
- Other medicines used to reduce high blood pressure (e.g. reserpine and guanethidine)
- Medicines used to treat other heart conditions like heart failure, abnormal heartbeat (e.g. prazosin, phentolamine, digoxin)
- Medicines used to treat allergies (e.g. fluticastone)
- Medicines used to treat thyroid disorders (e.g. levothyroxine)
- Medicines used to treat depression (e.g. fluoxetine, sertraline, amitriptyline)
- Medicines which relieve nasal congestion relievers (e.g. dexamethasone)
- Medicines that narrow blood vessels (e.g. phenylephrine, dopamine)
- Sympathomimetic agents (e.g. ephedrine)
- Steroids (used to treat inflammation) e.g. fludrocortisone acetate
Store below 20-25°C and keep out of reach of children.
FAQ’s ABOUT JOLAVI
Q: Can JOLAVI cause increase in heart rate?
A: Yes. It may cause increase in heart rate in some individuals. Consult your doctor for advice.
Q: Can JOLAVI be used in children?
A: No. This medicine is not recommended for use in children and adolescents under the age 18.