LuciDabra 75mg, Dabrafenib Capsules
LuciDabra 75mg, containing the active ingredient dabrafenib, is a targeted therapy medication primarily used in the treatment of certain cancers harboring specific genetic mutations. It is marketed by Lucius Pharmaceuticals and is indicated for various malignancies with BRAF V600E or V600K mutations.
This guide provides detailed information on its indications, dosage, administration, side effects, storage, benefits, interactions, frequently asked questions (FAQs), and conclusions
What is LuciDabra?
LuciDabra 75mg is a pharmaceutical product manufactured by Lucius Pharmaceuticals, Laos. It contains dabrafenib, a selective BRAF inhibitor that targets specific mutations in the BRAF gene, notably V600E and V600K. These mutations are implicated in various cancers, including melanoma, non-small cell lung cancer (NSCLC), and anaplastic thyroid cancer (ATC). LuciDabra is utilized to treat these cancers in patients harboring the aforementioned mutations.
Indications
LuciDabra is indicated for:
- Melanoma having a BRAF V600E mutation that is incurable or has spread.
- Unresectable or metastatic melanoma with BRAF V600K mutation, in combination with trametinib.
- Adjuvant treatment for melanoma with BRAF V600E or V600K mutations and lymph node involvement, following complete resection.
- BRAF V600E mutation-related metastatic non-small cell lung cancer (NSCLC).
- Anaplastic thyroid carcinoma (ATC) with a BRAF V600E mutation that has spread locally or metastasized and for which there are no effective locoregional therapy options.
- It is crucial to remember that patients with wild-type BRAF melanoma, wild-type BRAF NSCLC, or wild-type BRAF ATC should not be treated with LuciDabra.
Dosage and Administration
- Recommended Dose: 150 mg orally twice daily.
- Administration: Take this medication at least one hour before or two hours after eating.
- Formulation: Do not chew or crush the capsules; instead, consume them whole.
- missing Dose: Unless it falls within six hours of the subsequent dose, take the missing dose as soon as you remember. If so, omit the missing dose and get back to your usual routine.
- Storage: Keep between 20°C and 25°C in a dry location.
Side Effects
Common side effects include:
- Fever
- Fatigue
- Headache
- Nausea and vomiting
- Diarrhea
- Joint and muscle pain
- Skin rash
- Loss of appetite
- Hair loss
- Swelling of hands or feet
Serious side effects may include:
- Severe skin reactions (e.g., blistering, peeling)
- Eye inflammation (e.g., uveitis)
- Heart problems (e.g., cardiomyopathy)
- Liver toxicity
- Hemorrhage
- Hyperglycemia
- New malignancies
- Regular monitoring and prompt medical attention are essential
Storage
- Conditions: Keep between 20°C and 25°C in a dry location.
- Precautions: To keep the capsules dry, keep the silica gel desiccant in the vial.
- Safety tip: Keep dogs and youngsters away.
Benefits
- Targeted Therapy: Specifically inhibits BRAF V600E/K mutations, leading to reduced tumor growth.
- Efficacy: Demonstrated improved progression-free survival in clinical trials.
- Combination Therapy: When used with trametinib, offers enhanced efficacy in treating BRAF-mutant cancers.
- Oral Administration: Provides a convenient oral dosing schedule compared to some injectable therapies.
Prescription and Administration
LuciDabra should be prescribed by a healthcare professional experienced in the use of anti-cancer therapies. Regular monitoring and follow-up are essential to assess the efficacy and manage any adverse effects.
Drug Interactions
LuciDabra may interact with various medications:
Increased Dabrafenib Levels:
- Strong CYP3A4 inhibitors (e.g., ketoconazole)
- Strong CYP2C8 inhibitors (e.g., gemfibrozil)
Decreased Dabrafenib Levels:
- Strong CYP3A4 inducers (e.g., rifampin)
- Strong CYP2C8 inducers (e.g., rifampin)
Reduced Efficacy:
- Hormonal contraceptives
- Warfarin
- Midazolam
- Dexamethasone
FAQS
How should LuciDabra be taken?
Take 150 mg orally twice daily, at least 1 hour before or 2 hours after a meal.
Is LuciDabra safe during pregnancy?
No, LuciDabra can cause fetal harm and should not be used during pregnancy.
What is LuciDabra used for?
It treats cancers with BRAF V600E or V600K mutations, such as melanoma, NSCLC, and ATC.
Can LuciDabra cause side effects?
Yes, it may cause fatigue, fever, rash, nausea, joint pain, and other side effects.
Consult your healthcare provider before taking LuciDabra with other medications to avoid potential interactions.
Conclusion
LuciDabra 75mg (dabrafenib) is a targeted therapy offering significant benefits in treating cancers with BRAF V600E or V600K mutations. While effective, it requires careful monitoring for side effects and potential drug interactions. Patients should adhere to prescribed dosages and consult healthcare providers regularly to ensure optimal outcomes.
