LuciPazo 200mg, Pazopanib Tablets

LuciPazo 200mg is a branded formulation of Pazopanib, a potent oral tyrosine kinase inhibitor (TKI) used in oncology. This medication plays a critical role in treating specific types of cancer by targeting and inhibiting pathways that help cancer cells grow and spread. LuciPazo is manufactured to provide a reliable and effective therapeutic option for patients battling advanced kidney cancer and soft tissue sarcoma.

What is LuciPazo 200mg (Pazopanib)?

LuciPazo 200mg contains Pazopanib hydrochloride, an anti-cancer drug categorized as a multi-targeted tyrosine kinase inhibitor. It interferes with tumor growth and angiogenesis by inhibiting several receptor tyrosine kinases, such as VEGFR (vascular endothelial growth factor receptor), PDGFR (platelet-derived growth factor receptor), and c-Kit.

This drug is particularly used in patients with renal cell carcinoma (RCC) and advanced soft tissue sarcoma (STS) who have received prior chemotherapy.

How It Works / Mechanism of Action

Pazopanib exerts its anti-tumor activity by targeting and inhibiting a group of enzymes known as tyrosine kinases, which are responsible for cell signaling, growth, and survival. Specifically, LuciPazo:

• Blocks angiogenesis: Inhibits VEGFR-1, VEGFR-2, and VEGFR-3 to reduce the formation of new blood vessels that supply the tumor.
• Prevents tumor cell proliferation: Inhibits PDGFR and c-Kit, which are involved in the development and growth of cancerous cells.
• By cutting off the blood supply and interfering with cell growth signals, LuciPazo slows or stops the progression of cancer.

How to Use / Indications

LuciPazo 200mg is prescribed for the treatment of:

• Advanced Renal Cell Carcinoma (RCC) – A common form of kidney cancer.
• Advanced Soft Tissue Sarcoma (STS) – A diverse group of malignant tumors affecting connective tissues.
• It is often used as a second-line treatment after failure or intolerance to other therapies.

How to Take / Dosage

The typical recommended dose of Pazopanib is:

• Take 800 mg once a day, empty-handed (at least one hour before or two hours after a meal).
• Since LuciPazo comes in 200 mg tablets, the full dose is typically achieved by taking 4 tablets together once a day.

Important Guidelines:

• Take at the same time each day.
• Do not split, crush, or chew the tablets.
• Swallow whole with water.

Other Dosage Forms & Strengths

Pazopanib is available in:

• 200 mg tablets (like LuciPazo)
• 400 mg tablets (other brands)
• In cases of toxicity or liver impairment, the doctor may reduce the dosage (e.g., 600 mg or 400 mg daily).

Side Effects

Like all medications, LuciPazo may cause side effects. These can range from mild to severe:

Common Side Effects:

• Diarrhea
• High blood pressure (hypertension)
• Hair color changes (hypopigmentation)
• Nausea or vomiting
• Fatigue
• Decreased appetite
• Weight loss

Serious Side Effects:

• Liver dysfunction (elevated liver enzymes)
• Heart rhythm problems (QT prolongation)
• Blood clots or bleeding
• GI perforation
• Protein in urine (proteinuria)
• Liver Monitoring is essential during treatment as liver toxicity can be severe or even fatal in rare cases.

Storage

To ensure effectiveness and safety:

• Store at room temperature (20–25°C or 68–77°F)
• Keep away from direct sunlight, moisture, and heat
• Store in the original packaging to protect from humidity
• Keep out of reach of children

Benefits

LuciPazo 200mg offers several advantages in the management of advanced cancers:

• Convenient oral dosing avoids the need for injections or IVs
• Targeted therapy limits damage to healthy cells
• Effective in prolonging progression-free survival
• enhances cancer patients’ quality of life and symptoms
• A valuable option when other treatments have failed

Prescription

LuciPazo 200mg is a prescription-only medicine and should be used strictly under oncologist supervision. The doctor will:

• Evaluate the stage and type of cancer
• Monitor liver and kidney function
• Adjust the dose if needed
• Review interactions with other drugs
• Never start or stop treatment without professional guidance.

Drug Interactions

LuciPazo interacts with several medications. Inform your doctor if you’re taking:

Drugs that increase Pazopanib levels:

• Ketoconazole, Itraconazole (antifungals)
• Clarithromycin (antibiotic)
• Ritonavir (HIV drug)

Drugs that decrease Pazopanib levels:

• Rifampin (antibiotic)
• Phenytoin, Carbamazepine (anti-seizure meds)

Other Considerations:

• Avoid grapefruit juice, which affects drug metabolism.
• Antacids or PPIs may reduce absorption—space their use.
• Always disclose all medicines, supplements, and herbal products to your doctor.

FAQs

Can LuciPazo be taken with food?

No. It must be taken on an empty stomach to ensure proper absorption.

Can LuciPazo cure cancer?

No, it is not a cure but helps in controlling cancer, prolonging life, and reducing symptoms.

How long can I take LuciPazo?

You can take it as long as it’s effective and tolerated; your doctor will monitor progress regularly.

Is hair loss a side effect of LuciPazo?

Hair loss is rare; more commonly, it may cause hair color changes.

Conclusion

LuciPazo 200mg (Pazopanib) is an important oral targeted therapy for treating advanced kidney and soft tissue cancers. Its ability to inhibit tumor growth and angiogenesis has made it a key component in cancer management. While it provides significant benefits, careful monitoring and adherence to dosing guidelines are essential for safety and efficacy.

Patients should work closely with their healthcare team to manage side effects, evaluate progress, and ensure optimal use of LuciPazo in their cancer treatment journey.