INTRODUCTION OF MITOMYCIN 2
MITOMYCIN 2 contains Mitomycin which belongs to a group of medicines called anti-neoplastic agent
WHAT MITOMYCIN 2 IS USED FOR?
- Advanced metastatic stomach cancer (stomach carcinoma)
- Advanced and/or metastatic breast cancer (breast carcinoma)
- Cancer of the respiratory tract (non-small cell bronchial carcinoma)
- Advanced cancer of the pancreas (pancreatic carcinoma)
- It is also used for the prevention of a relapse in the case of superficial urinary bladder
- cancer after the ablation of tissue through the urethra (transurethral resection)
WARNINGS AND PRECAUTIONS
TALK TO DOCTOR
- Are allergic to any of the other ingredients of this medicine
- Are suffering from impaired lung, kidney or liver function
- Are undergoing radiation therapy
- Are being treated with other cytostatics (substances which inhibit cell growth/cell division)
- Have inflammation of the urinary bladder (in case of intravesical administration)
- Have been told that you have bone marrow depression
- Are immunized with live virus vaccine as this increase risk of infection
PREGNANCY & BREAST FEEDING
If you are pregnant or breastfeeding, think you may be pregnant or are planning to have a baby, ask your doctor for advice before taking this medicine
CHILDREN & ADOLESCENTS
The use of MITOMYCIN 2 in children and adolescents is not recommended
DRIVING & USING MACHINES
It may cause nausea and vomiting and thereby reduce your reaction times to such an extent that the ability to drive a motor vehicle or operate machinery is impaired. This applies in conjunction with alcohol
INTERACTIONS
Tell your doctor if you are taking,
Anti-cancer drugs (used to treat cancer)
Vaccines
DIRECTIONS & FOR USE
- MITOMYCIN 2 must only be given by a doctor or nurse
- It is intended to be used for injection or infusion into a blood vessel (intravenous use) or for introduction into the urinary bladder (intravesical instillation)
- If you have been accidentally given a higher dose you may experience symptoms such as fever, nausea, vomiting and blood disorders. Your doctor may give you supportive treatment for any symptoms that may occur
- If you miss your scheduled injection, contact your doctor or nurse
- Do not stop taking this medicine unless your doctor tells you to do so
SIDE EFFECTS OF MITOMYCIN 2
SERIOUS EFFECTS OF MITOMYCIN 2
- Shortness of breath
- Dry cough and crackles during breath-in (interstitial pneumonia)
- Severe renal dysfunction (nephrotoxicity)
COMMON EFFECTS OF MITOMYCIN 2
- Blood disorders: inhibition of blood cell production in the bone marrow
- Decreased number of white blood cells (leucopenia) increasing the risk of infections
- Decreased number of platelets (thrombocytopenia) causing bruises and bleedings
- Nausea, vomiting
- Lung disorders presenting as shortness of breath, dry cough and inspiratory crackles (interstitial pneumonia)
- Dyspnea, cough, shortness of breath
- Skin rashes and irritation of the skin
- Numbness, swelling and painful redness on palms and soles (palmar-plantar erythema)
Kidney disorders (renal dysfunction, nephrotoxicity, glomerulopathy, increased levels of creatinine in the blood) - Inflammation of connective tissue (cellulitis) and death of tissue (tissue necrosis)
- following accidental injection into the surrounding tissue (extravasation)
- Skin rashes (exanthema, allergic skin rash, contact dermatitis)
- Numbness, swelling and painful redness on palms and soles (palmar-plantar erythrodysaesthesia (PPE)/hand-foot syndrome) Bladder inflammation (cystitis) – which may be accompanied with blood in the bladder/urine Painful urination, excessive frequent urination sometimes over the night (dysuria, pollakisuria, nocturia)
- Blood in urine (hematuria)
- Local irritation of the bladder wall
UNCOMMON EFFECTS OF MITOMYCIN 2
- Inflammation of a mucous membrane (mucositis)
- Inflammation of the mucosa of the mouth (stomatitis)
- Diarrhoea, fever
- VHair loss (alopecia)
- Loss of appetite (anorexia)
RARE EFFECTS OF MITOMYCIN 2
- Life-threatening infection Blood poisoning (sepsis)
- Decrease in number of red blood cells sometimes together with acute renal dysfunction (hemolytic anemia, microangiopathic-hemolytic anemia), hemolytic uraemic syndrome
Loss of cardiac function (heart failure) after previous therapy with other anti-cancer - medicines (anthracyclines)
- Increase in blood pressure in the vasculature of the lungs, e.g., leading to shortness of breath, dizziness and fainting (pulmonary hypertension)
- Obstructive disease of the pulmonary veins (pulmonary veno-occlusive disease)
- Liver dysfunction
- Increased levels of liver enzymes (transaminases)
- Widespread skin rash
VERY RARE EFFECTS OF MITOMYCIN 2
- Faintness
- Skin rash or hives, itching
- Swelling of lips
- Face and airway with difficulty in breathing
- Loss of consciousness
- Severe inflammation of the bladder where portions of the bladder wall may undergo tissue death (allergic cystitis, necrotizing cystitis)
- Stenosis of the efferent urinary tract
- Reduction in bladder capacity
- Hardening of bladder wall (bladder wall calcification, bladder wall fibrosis)
STORAGE
- Keep this medicine out of reach of children
- Store at a room temperature of 15-25°C
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