MYELOSTAT 500MG contains Hydroxyurea which belongs to the group of medicines called antineoplastic agents. It is indicated for the treatment of resistant chronic myelocytic leukemia (blood cell cancer), ovarian cancer and skin cancer (melanoma). It can also be used to treat locally advanced squamous cell carcinomas of head and neck in combination with chemoradiation.
Inside the cells, hydroxyurea causes an immediate inhibition of DNA synthesis by inhibiting the enzyme ribonucleotide reductase and produces cell death in S phase. Your doctor will decide the correct dose for you depending upon your condition. Continue to take this medicine, as long as your doctor tells you to do so, to obtain better results.
The most common side effects are nausea, vomiting, loss of appetite and constipation. Hydroxyurea may harm an unborn baby. Both women and men using this medicine should use birth control to prevent pregnancy, because the use of this medicine by either parent may cause birth defects. Before taking this medicine, inform your doctor if you have any marked bone marrow depression, severe anemia, liver or kidney disease.
USES OF MYELOSTAT 500MG:
Resistant chronic myelocytic leukemia
Melanoma (skin cancer)
Locally advanced squamous cell carcinomas of head and neck
HOW MYELOSTAT 500MG WORKS:
Following oral administration, hydroxyurea is converted to free radical nitroxide (NO) and enters into the cells, which inactivates the enzyme ribonucleotide reductase. Inactivation of this enzyme causes an immediate inhibition of DNA synthesis and produces cell death in S phase.
DIRECTIONS FOR USE:
Take MYELOSTAT 500MG as directed by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose for you depending upon your condition. Continue to take this medicine, as long as your doctor tells you to do so, to obtain better results.
SIDE EFFECTS OF MYELOSTAT 500MG:
• Numbness, tingling, or burning pain in your hands or feet
• Skin numbness or purple discoloration
• Skin ulcers or open sores
• Sudden chest pain and wheezing
• Upper stomach pain
• Fast heart rate
• Dark urine
• Jaundice (yellowing of the skin or eyes)
• Loss of appetite
• Nausea or vomiting
• Constipation, diarrhea
• Low blood cell counts
• Mouth sores
HOW TO MANAGE SIDE EFFECTS:
Nausea or vomiting:
Try taking this medicine with, or just after meal. Stick to simple meals. Do not eat rich or spicy food.
Eat fibre rich foods like fresh fruit, vegetables and cereals. Drink plenty of water. Exercise more regularly.
Drink lots of fluids, such as water or juice, to avoid dehydration. Do not take any medicines without speaking to a doctor.
WARNINGS AND PRECAUTIONS:
MYELOSTAT 500MG should be used with caution in pregnant women. Consult your doctor before taking.
MYELOSTAT 500MG should be used with caution in breast feeding women. Consult your doctor before taking.
DRIVING AND USING MACHINES
Do not drive or operate any machines if your ability is affected by this medicine.
Avoid consumption of alcohol while taking this medicine.
MYELOSTAT 500MG should be taken with caution in patients with severe kidney disease. Consult your doctor for advice.
MYELOSTAT 500MG should be taken with caution in patients with severe liver disease. Consult your doctor for advice.
Do not take this medicine if you are allergic (hypersensitive) to hydroxyurea.
Do not take this medicine, if you:
Have a marked bone marrow depression, leukopenia (decreased WBC count), thrombocytopenia (decreased platelet count), severe anemia (decreased RBC count) or HIV infection
Talk to your doctor, if you are taking,
Other myelosuppressive agents (anti-cancer medicines) e.g. peginterferon alpga-2A, rituximab, alentuzumab
Live viral vaccine (varicella vaccine, MMR vaccine)
Antiretroviral Drugs (used to treat HIV) e.g. abacavir, didanosine, zidovudine
Drug : Hydroxyurea
Pharmacological Category : Anti-neoplastic agent
Therapeutic Indication : Resistant chronic myelocytic leukemia, Ovarian cancer, Melanoma, squamous cell carcinomas of head and neck
Dosage Forms : Capsule
Store below 20-25°C and keep out of reach of children.
FAQ’s ABOUT MYELOSTAT 500MG:
Q: Can MYELOSTAT 500MG cause liver damage?
A: Yes. It may cause liver damage in some individuals. Check with your doctor.
Q: Can MYELOSTAT 500MG be used during pregnancy?
A: No. It may harm an unborn baby. It is not recommended for use in pregnancy.
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