INTRODUCTION:

Celonib 400Mg contains Imatinib mesylate which belongs to a group of medicines called corticosteroids which reduces infl?ammation. It is indicated to treat chronic myeloid leukaemia and Philadelphia chromosome positive acute lymphoblastic leukaemia in adults and children.

Leukaemia is a cancer of white blood cells, the cells usually help the body to fight infection. CELONIB 400MG also used to treat myelodysplastic/myeloproliferative diseases, hypereosinophilic syndrome (HES) and/or chronic eosinophilic leukaemia, gastrointestinal stromal tumours and dermatofibrosarcoma protuberans in adults. Tyrosine kinases are proteins which act as chemical messengers that are used by the cancer cells to signal to each other for their growth. This medicine works by blocking this enzyme and stops the cancer cells from growing.

Take this medicine according to the dose and frequency as advised by your doctor. Swallow whole with a large glass of water. It can be taken with food. The common side effects are fluid retention, weight gain. Before taking this medicine tell your doctor if you have kidney, liver or heart problems. It is not recommended during pregnancy and breastfeeding.

USES OF CELONIB 400MG:

Chronic myeloid leukaemia
Philadelphia chromosome positive acute lymphoblastic leukaemia
Myelodysplastic/myeloproliferative diseases
Hypereosinophilic syndrome (HES) and/or chronic eosinophilic leukaemia
Gastrointestinal stromal tumours
Dermatofibrosarcoma protuberans

HOW CELONIB 400MG WORKS:

CELONIB 400MG is a protein-tyrosine kinase inhibitor. Tyrosine kinases are proteins which act as chemical messengers that are used by the cancer cells to signal to each other for their growth. Imatinib mesylate by blocking this enzyme stops the cancer cells from growing.

DIRECTIONS FOR USE:

Take this medicine according to the dose and frequency as advised by your doctor. Swallow whole with a large glass of water. It can be taken with food.

SIDE EFFECTS OF CELONIB 400MG:

COMMON

• Rapid weight gain (severe fluid retention)
• Fever, severe chills
• Sore throat
• Mouth ulcers
• Unexpected bleeding or bruising

WARNING AND PRECAUTIONS:

PREGNANCY

CELONIB 400MG is not recommended for use in pregnant women unless necessary. Discuss the risks and benefits with your doctor.

BREASTFEEDING

CELONIB 400MG is not recommended for use in breastfeeding women unless necessary. Discuss the risks and benefits with your doctor.

DRIVING AND USING MACHINES

Do not drive or operate machinery while taking this medicine, since it may cause dizziness, drowsiness or blurred vision.

KIDNEY

CELONIB 400MG should be used with caution in patients suffering from active kidney diseases. Consult your doctor for advice.

LIVER

CELONIB 400MG should be used with caution in patients suffering from liver function impairment or active liver diseases. Consult your doctor for advice.

ALLERGY

Do not take if you are allergic (hypersensitive) to Imatinib.

HEART DISEASE

CELONIB 400MG should be used with caution in patients suffering from active heart diseases. Consult your doctor for advice.

OTHERS

Inform your doctor if you have,

Hepatitis B infection

INTERACTIONS:

Inform your doctor if you are taking or have recently taken any other medicines, including medicines obtained without a prescription or the following,

Levothyroxine
Paracetamol
Herbal medicines (St. John?s Wort)
Medicines used to prevent the formation of blood clots

SYNOPSIS:

Drug : Imatinib
Pharmacological Category : Antineoplastic Agent, BCR-ABL Tyrosine Kinase Inhibitor
Therapeutic Indication : Leukemia, Gastrointestinal stromal tumors
Dosage Forms : Tablet

MORE INFORMATION:

Store below 20-25°C and keep out of reach of children.

FAQ’s ABOUT CELONIB 400MG:

Q: Can use CELONIB 400MG during pregnancy?
A: This medicine is not recommended during pregnancy, or if you are planning to get pregnant.

Q: Does CELONIB 400MG safe while driving?
A: Do not drive or operate any machines since it may cause dizziness, drowsiness or blurred vision

Q: What causes chronic myeloid leukaemia?
A: It is caused by a genetic change in the stem cells produced by the bone marrow which causes the stem cells to produce too many underdeveloped white blood cells.

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Celonib 400Mg Tablet 10’s