INTRODUCTION
CIZUMAB 400 contains Bevacizumab which belongs to a group of medicines called antiangiogenic agents. It is indicated to treat metastatic colorectal cancer, first-line non-squamous non small cell lung cancer, recurrent glioblastoma (GBM), metastatic renal cell carcinoma, persistent, recurrent, or metastatic cervical cancer, epithelial ovarian, fallopian tube, or primary peritoneal cancer and hepatocellular carcinoma.
Bevacizumab is a humanized monoclonal IgG1 antibody which contains human framework regions and murine complementarity determining regions. This binds VEGF and prevents the interaction of VEGF to its receptors (Flt-1 and KDR) on the surface of endothelial cells. This interaction of VEGF with its receptors leads to endothelial cell proliferation and new blood vessel formation in invitro models of angiogenesis. Bevacizumab reduces microvascular growth and inhibition of metastatic disease progression.
Before receiving this CIZUMAB 400, tell your physician if you have liver, kidney or heart problems, are pregnant or breastfeeding. This medicine is not suitable for use in children and adolescents below 18 years of age. The common side effects are nose or rectal bleeding, headache, back pain or increased blood pressure.
USES OF CIZUMAB 400
Treats,
- Metastatic colorectal cancer
- First-line non-squamous non small cell lung cancer
- Recurrent glioblastoma (GBM)
- Metastatic renal cell carcinoma
- Persistent, recurrent, or metastatic cervical cancer
- Epithelial ovarian
- Fallopian tube, or primary peritoneal cancer and
- Hepatocellular carcinoma
HOW CIZUMAB 400 WORKS
Bevacizumab belongs to antiangiogenic agents which works by stopping the formation of blood vessels that bring oxygen and nutrients to tumors and slows the growth and spread of tumors.
DIRECTIONS FOR USE
CIZUMAB 400 will be administered as an intravenous infusion by your doctor or nurse.
SIDE EFFECTS OF CIZUMAB 400
COMMON
- Nosebleed or rectal bleeding
- Increased blood pressure
- Headache
- Back pain
- Dry or watery eyes
- Flaky or dry skin
- Runny nose or sneezing
- Changes in your sense of taste
HOW TO MANAGE SIDE EFFECTS
Headache:
Rest and drink plenty of fluids. Apply a wet or cold cloth to forehead and rest in a quiet, comfortable, dark room.
Back pain:
Use an ice pack or over the counter medicines to relieve pain.
WARNING & PRECAUTIONS
PREGNANCY
CIZUMAB 400 is not recommended for use in pregnant women unless necessary. Discuss the risks and benefits with your Doctor.
BREASTFEEDING
CIZUMAB 400 is not recommended for use in breastfeeding women unless necessary. Discuss the risks and benefits with your Doctor.
KIDNEY
CIZUMAB 400 should be used with caution in patients suffering from kidney diseases. Consult your doctor for advice.
LIVER
CIZUMAB 400 should be used with caution in patients suffering from liver function impairment or active liver diseases. Consult your doctor for advice.
ALLERGY
Tell your doctor if you are allergic (hypersensitive) to Bevacizumab.
LUNGS
CIZUMAB 400 should be used with caution in patients suffering from chronic lung disease. Consult your doctor for advice.
HEART DISEASE
CIZUMAB 400 should be used with caution in patients suffering from active heart diseases. Consult your doctor for advice.
OTHERS
Tell your doctor before taking this medicine if you have or had:
- Ovarian cancer
- Hemoptysis
- Arterial thromboembolism
- Diabetes
- Pulmonary embolism
- Hypertension
INTERACTIONS
Tell your doctor if you are taking,
- Paclitaxel
- Carboplatin
SYNOPSIS
| Drug | : | Bevacizumab |
| Pharmacological Category | : | Antiangiogenic agents |
| Therapeutic Indication | : | Metastatic colorectal cancer, First-line non-squamous non small cell lung cancer, Hepatocellular carcinoma |
| Dosage Forms | : | Injection |
MORE INFORMATION
- Keep out of reach of children
- Store at 2 – 8°C
FAQs ABOUT CIZUMAB 400
Can CIZUMAB 400 be used during pregnancy?
It is not suitable for use in pregnant women, unless prescribed by your doctor.
How CIZUMAB 400 works differently from chemotherapy?
It prevents the growth of new blood vessels that feed tumors and causes the tumour to shrink, or to stop growing.
How is CIZUMAB 400 given?
It will be administered intravenously by your doctor or nurse.
