Eudaxen 25mg, Diazoxide Tablets

Eudaxen 25mg is a pharmaceutical formulation containing Diazoxide, a potent medication primarily used in the management of hypoglycemia (low blood sugar levels) and hypertension in emergency settings. Diazoxide belongs to a class of drugs known as potassium channel activators and is widely recognized for its dual role in inhibiting insulin release from the pancreas and lowering blood pressure by relaxing vascular smooth muscles. Eudaxen 25mg  is often prescribed in specialized clinical settings due to its potent pharmacological effects.

What is Eudaxen 25mg?

Eudaxen 25mg is a prescription medication that contains Diazoxide as its active ingredient. Although diazoxide, a derivative of benzothiadiazine, shares chemical similarities with thiazide diuretics, its pharmacological actions are very different. It is used as a hyperglycemic and vasodilator instead of a diuretic.

This drug is commonly used to:

• Treat acute hypoglycemia in conditions such as insulinoma (insulin-secreting tumors).
• Control hypertensive emergencies.

How it Works / Mechanism of Action

Diazoxide works through two primary mechanisms:

Inhibition of Insulin Secretion:

• In beta cells of the pancreas, dialzoxide opens ATP-sensitive potassium (KATP) channels.
• This hyperpolarizes the cell membrane, preventing the calcium influx needed for insulin secretion.
• As a result, insulin release is suppressed, increasing blood glucose levels.

Vasodilation:

Diazoxide opens potassium channels in blood vascular smooth muscle cells.

This action relaxes arterial smooth muscles, resulting in vasodilation and reduced blood pressure.

How to Use / Indications

Indications for Eudaxen 25mg :

• Hypoglycemia due to hyperinsulinism (e.g., insulinomas, nesidioblastosis)
• Persistent hypoglycemia in infants or adults
• Hypertensive crisis (intravenous form preferred for acute management)
• Malignant hypertension (in select cases)
• This medication is generally used when first-line treatments have failed or in conditions requiring specialized intervention.

How to Take / Dosage

Standard Dosage for Adults:

• Hypoglycemia: Initial dose of 3–8 mg/kg/day orally in 2–3 divided doses.
• Adjust dose based on blood glucose response.
• Maximum dose typically does not exceed 15 mg/kg/day.

For Pediatric Patients:

• Doses are carefully calculated based on weight.
• Used under strict medical supervision due to potential adverse effects on growth and metabolism.

Administration Tips:

• Take the tablet orally with or without food.
• Use a consistent schedule for better results.
• Blood glucose levels must be closely monitored during treatment.

Other Dosage Forms

Apart from the 25mg oral tablets (like Eudaxen 25mg ), Diazoxide is also available in:

• Suspension form for pediatric use.
• Intravenous (IV) formulation for emergency treatment of hypertensive crises.
• The choice of formulation depends on the clinical condition, urgency, and patient-specific factors.

Side Effects

Common Side Effects:

• Hyperglycemia (high blood sugar)
• Fluid retention and edema
• Nausea or vomiting
• Increased uric acid levels (possible gout)
• Hirsutism (excess hair growth, especially in children)

Serious Side Effects:

• Congestive heart failure due to fluid overload
• Leukopenia or thrombocytopenia
• Hypotension
• Pulmonary hypertension (especially in neonates)

Monitoring Required:

• Blood glucose levels
• Renal and hepatic function
• Blood pressure
• Electrolytes

Storage

• Store Eudaxen 25mg  in a cool, dry place, away from direct light and moisture.
• Ideal temperature: 15°C to 30°C (59°F to 86°F).
• Keep out of reach of children.
• Do not use beyond the expiry date printed on the package.

Benefits

• Rapid correction of hypoglycemia in insulin-secreting disorders.
• Non-surgical management option for insulinomas.
• Helps avoid frequent hospitalizations in chronic hypoglycemia.
• Effective in emergency management of hypertensive crises (in IV form).
• Beneficial in infants and children with congenital hyperinsulinism, when surgery is not immediately feasible.

Prescription

Eudaxen 25mg is a prescription-only medicine (Rx) due to its powerful effects and risk of side effects. It should be:

• Prescribed by an endocrinologist, pediatric specialist, or hypertension expert.
• Dispensed under medical supervision with regular follow-ups.

Drug Interactions

Potential Interactions Include:

• Antidiabetic medications (may counteract their effect)
• Diuretics (risk of fluid retention or electrolyte imbalance)
• Antihypertensive medications (risk of a disproportionate reduction in blood pressure)
• Corticosteroids (may increase risk of hyperglycemia)

Avoid combining with:

• Phenytoin (may reduce diazoxide effectiveness)
• Sulfonylureas (opposing effects—sulfonylureas stimulate insulin, diazoxide inhibits)

FAQs

Is this drug safe for infants?

It can be use in infants with congenital hyperinsulinism, but only under specialist supervision with close monitoring.

How long can I take Diazoxide?

Duration depends on the condition being treate. Long-term use is possible but requires regular follow-ups.

Can it cause weight gain?

Yes, due to fluid retention and increased appetite in some cases.

Conclusion

Eudaxen 25mg (Diazoxide) is a valuable medication for managing complex conditions like persistent hypoglycemia and hypertensive emergencies. Its ability to inhibit insulin secretion and induce vasodilation makes it unique, but also necessitates cautious use. With proper monitoring and professional oversight, it offers a life-saving option in specific clinical scenarios. However, due to potential side effects and interactions, it must be used only under prescription and medical supervision. Understanding its use, mechanism, dosage, and precautions can empower patients and caregivers to navigate treatment more confidently and safely.