Rulifast 15mg, Ruxolitinib Cream

Rulifast 15mg, a topical formulation of Ruxolitinib Cream, is an innovative dermatological treatment used for various inflammatory skin conditions. It is a member of the group of drugs known as Janus kinase (JAK) inhibitors. Ruxolitinib, previously used in oral form for hematological disorders, has now been effectively adapted for topical use, offering a novel therapy for diseases like atopic dermatitis and vitiligo. The formulation in Rulifast 15mg cream provides localized action, minimizing systemic side effects and offering targeted relief.

What is Rulifast 15mg?

Rulifast 15mg contains Ruxolitinib phosphate, a potent and selective JAK1/JAK2 inhibitor. It is presented as a white-to-off-white cream, primarily used to manage mild to moderate atopic dermatitis (eczema) and non-segmental vitiligo in patients aged 12 years and older. By modulating the immune response, it helps reduce inflammation, itching, and depigmentation in affected skin areas.

How It Works / Mechanism of Action

Ruxolitinib works by inhibiting Janus kinases (JAK1 and JAK2)—enzymes involved in the signal transduction of various cytokines and growth factors that mediate immune function and inflammation.

In conditions like atopic dermatitis, pro-inflammatory cytokines (e.g., IL-4, IL-13) are overproduced.

Ruxolitnib blocks the JAK-STAT (Signal Transducer and Activator of Transcription) pathway, thereby:

• Reducing cytokine-mediated inflammation
• Decreasing redness, swelling, and itching
• Stabilizing immune dysregulation in vitiligo by modulating interferon-gamma pathways
• This local inhibition limits skin inflammation without suppressing the overall immune system as seen in systemic treatments.

How to Use / Indications

Indications for Rulifast 15mg include:

• For individuals 12 years of age and up, atopic dermatitis is a short-term, non-continuous chronic therapy for mild to severe eczema.
• Vitiligo (Non-segmental) – to repigment areas of the skin, especially facial and hand involvement.

Off-label uses (under medical supervision) may include:

• Psoriasis
• Lichen planus
• Alopecia areata

How to Take / Dosage

Recommended Dosage:

• For adults and adolescents aged 12 and above, apply a thin coating to the afflicted regions twice a day.
• Maximum total dosage: not to exceed 60 grams per week.

Important Points:

• Wash and dry hands before and after applying the cream.
• Apply only on intact skin. Avoid broken, infected, or ulcerated areas.
• Do not use on the face, underarms, or groin unless directed by a physician.

Other Dosage Forms

Although the topical formulation is Rulifast 15mg, rufolitinib is also offered in:

Oral Tablets – used for systemic conditions like:

• Myelofibrosis
• Polycythemia vera
• Graft-versus-host disease (GVHD)
• Topical 1.5% and 1% formulations – for dermatological use, depending on regional regulatory approval.

Side Effects

Common Side Effects:

• Application site reactions (burning, stinging, itching)
• Acne
• Nasopharyngitis
• Headache
• Less Common but Serious:
• Herpes simplex infections (cold sores)
• Bacterial skin infections
• Reactivation of tuberculosis or shingles (rare with topical use)
• Monitoring: Patients using Ruxolitinib cream should be monitored for signs of infection or allergic reactions.

Storage

• Temperature: Store at 20°C to 25°C (68°F to 77°F); excursions between 15°C–30°C permitted.
• Container: Keep in original tube; tightly closed.
• Shelf Life: Refer to the expiration date on the packaging.
• Do not freeze.
• Keep out of reach of children and do not use after expiration.

Benefits

• Targeted Action: Has little systemic absorption and acts locally.
• Fast Relief: Reduces itching and inflammation within 1–2 weeks.
• Effective for Repigmentation: Especially in vitiligo, it stimulates melanocyte function.
• Steroid-Sparing: Avoids long-term complications of corticosteroids like skin thinning or stretch marks.
• Convenient Application: Non-greasy, easy-to-apply cream.

Prescription

• The drug Rulifast 15mg (ruxolitinib cream) is only available with a prescription.
• Prescribed by dermatologists or immunologists.
• Not available over-the-counter due to potential risks and need for professional supervision.
• Treatment duration and frequency should be monitored by a healthcare provider.

Drug Interactions

Topical Ruxolitinib has minimal systemic absorption, so interactions are rare. However:

Caution with:

• Live vaccines – Avoid during treatment.
• Immunosuppressive therapies – Combined effect may increase infection risk.
• Strong CYP3A4 inhibitors (like ketoconazole) – May increase systemic absorption if applied over large areas or damaged skin.
• Always inform your healthcare provider about any medications, supplements, or topical products you’re using.

FAQs

Can I use Rulifast 15mg cream on my face?

Only if prescribed. The face is more sensitive and may have a higher absorption rate, increasing side effects.

Is Rulifast a steroid?

No. It is a JAK inhibitor, not a corticosteroid, and does not cause skin thinning.

Can it cure vitiligo?

It helps in repigmenting the skin, especially when used early, but it is not a permanent cure.

Conclusion

Rulifast 15mg (Ruxolitinib Cream) marks a breakthrough in the topical management of inflammatory skin conditions such as atopic dermatitis and vitiligo. By targeting specific immune pathways, it provides effective, steroid-free treatment with minimal systemic side effects. Proper application, patient adherence, and regular monitoring are key to achieving optimal therapeutic results. While it’s not a cure, Rulifast offers a significant improvement in quality of life for patients struggling with chronic skin conditions. Always consult your dermatologist for personalized guidance and safe usage.