LuciEver 5mg, Everolimus Tablets

LuciEver 5mg is a prescription medicine containing Everolimus, a potent mTOR (mammalian target of rapamycin) inhibitor. It is mostly used to treat cancer and keep transplant recipients from rejecting their organs. Manufactured under strict pharmaceutical standards, LuciEver offers a targeted therapy option for various cancers and certain non-oncological conditions.

What is LuciEver 5mg?

Everolimus, an oral immunosuppressive and anticancer medication, is present in LuciEver 5mg. Everolimus is classified as an mTOR inhibitor and is used for treating advanced cancers such as:

• Renal cell carcinoma (kidney cancer)
• Breast cancer (hormone receptor-positive, HER2-negative)
• Neuroendocrine tumors (NETs)
• Tuberous sclerosis complex (TSC)-associated tumors
• It is also used to prevent organ rejection after a kidney or liver transplant.

How Does It Work? / Mechanism of Action

A crucial protein in the PI3K/AKT/mTOR system, which regulates cell growth, proliferation, and survival, mTOR is inhibited by everolimus. By inhibiting mTOR:

• It slows down tumor cell growth.
• Prevents angiogenesis (formation of blood vessels feeding tumors).
• Suppresses immune response, which is useful in transplant patients.
• This targeted approach helps in reducing the growth of tumors while minimizing damage to normal cells.

How to Use / Indications

LuciEver 5mg is prescribed for several medical conditions, including:

• advanced renal cell carcinoma (RCC) following sunitinib or sorafenib treatment failure.
• exemestane-treated postmenopausal women with advanced HER2-negative, hormone receptor-positive breast cancer.
• Neuroendocrine tumors of pancreatic, lung, or gastrointestinal origin.
• renal angiomyolipoma and subependymal giant cell astrocytoma (SEGA), which are associated with TSC.
• prevention of organ rejection (in conjunction with other immunosuppressants) in recipients of liver or kidney transplants.

How to Take / Dosage

• Standard Dosage: LuciEver 5mg is usually taken once daily.
• It should be taken at the same time every day, consistently with or without food.
• Swallow the tablet whole with water—do not crush, chew, or split.

Other Dosages Available

LuciEver (Everolimus) is available in multiple strengths to allow dose customization:

• 2.5 mg
• 5 mg
• 7.5 mg
• 10 mg

These options support stepwise dose escalation or reduction depending on the patient’s condition, side effects, and laboratory values (especially blood levels in transplant patients).

Side Effects

Like all medications, LuciEver may cause side effects. These can vary based on dosage, indication, and patient health.

Common Side Effects:

• Mouth ulcers or sores
• Fatigue
• Rash
• Diarrhea
• Nausea
• Cough or respiratory infections
• Decreased appetite

Serious Side Effects:

• Non-infectious pneumonitis (lung inflammation)
• Kidney dysfunction
• Increased risk of infections
• Elevated blood sugar or cholesterol
• Delayed wound healing
• Liver problems
• Monitoring: Routine blood tests are essential during therapy to assess liver/kidney function, blood count, and Everolimus levels.

Storage

• Store LuciEver 5mg at room temperature (20–25°C).
• Keep away from moisture, heat, and direct light.
• Do not use the medicine after the expiration date.
• Keep out of reach of children and pets.

Benefits

• Targeted Therapy: Specifically blocks cancer cell growth with minimal effects on healthy cells.
• Versatility: Effective in various cancers and transplant care.
• Oral Convenience: Easily administered at home without the need for injections or infusions.
• Clinical Evidence: Proven in multiple global studies for effectiveness and safety.
• TSC Management: Effective in managing benign tumors in patients with Tuberous Sclerosis Complex.

Prescription

LuciEver 5mg is a prescription-only medicine. It must be prescribed and monitored by a healthcare provider experienced in oncology or transplant medicine. Never self-medicate or adjust doses without medical advice.

Drug Interactions

• Everolimus interacts with several drugs. It is metabolized in the liver via the CYP3A4 enzyme and affected by P-glycoprotein transporters.

Avoid:

• Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin) – can increase Everolimus levels, leading to toxicity.
• Strong CYP3A4 inducers, such as carbamazepine and rifampin, can decrease efficacy.                        
• Grapefruit juice – may increase drug levels.
• Live vaccines – risk of infection.
• Inform your doctor about all medications and supplements you are taking before starting LuciEver.

FAQs 

Is LuciEver chemotherapy?

No. It is a targeted therapy, not traditional chemotherapy.

How long can I take LuciEver?

As long as the doctor advises, based on disease response and tolerance.

Does it affect immunity?

Yes. It may suppress the immune system and increase infection risk.

How is it different from Sirolimus?

Both are mTOR inhibitors, but Everolimus has broader cancer use and improved pharmacokinetics.

Conclusion

LuciEver 5mg (Everolimus) is a powerful and versatile medicine offering hope to patients with advanced cancers and those undergoing organ transplantation. By targeting the mTOR pathway, it controls disease progression and improves survival outcomes. However, it needs to be administered under close medical care because of possible interactions and negative effects. Proper adherence to dosage, routine monitoring, and following your healthcare provider’s advice are crucial for safe and effective treatment.