About Cazanat 40mg Tablet
Cazanat 40mg Tablet is an anti-cancer medicine used in the treatment of renal cell carcinoma. It is a disease in which cancer cells grow uncontrollably in the kidney and form a tumor. Cazanat 40mg Tablet is used in treating advanced renal cell carcinoma as first-line therapy for advanced renal cell carcinoma in combination with nivolumab and hepatocellular carcinoma in patients who have previously been treated with sorafenib.
Cazanat 40mg Tablet contains Cabozantinib as an active ingredient, which belongs to the class of medicines known as kinase inhibitors. It works by inhibiting the action of an enzyme (tyrosine kinase) and thus stops the abnormal growth of cancer cells.
Cazanat 40mg Tablet may cause certain side effects such as diarrhea, decreased appetite, nausea, vomiting, increased blood pressure, muscle cramps, decreased weight, dizziness, and constipation. Inform your doctor if any of these side effects bother you. Cazanat 40mg Tablet should be taken as advised by your doctor.
Avoid taking Cazanat 40mg Tablet if you are allergic to it or any other components of it. Before taking Cazanat 40mg Tablet, inform your doctor if you have/had liver or kidney disease, gastrointestinal disorders, heart problems, blood or bleeding disorders, open or healing wounds, and a history of recent surgery. This medicine is known to cause embryo-fetal toxicity. Hence, it is not recommended for use in pregnancy and breastfeeding.
Uses Of Cazanat 40mg Tablet
- Renal Cell Carcinoma, Hepatocellular carcinoma.
Medicinal Benefits
Cazanat 40mg Tablet contains Cabozantinib, which is used in treating advanced renal cell carcinoma and liver cancer. It works by stopping the action of a tyrosine kinase enzyme that causes the multiplication of cancerous cells. This helps stop the abnormal growth of cancer cells and thus reduce the further spread to other parts of the body. It also decreases the blood supply to cancer tumors to slow down the growth of the tumor. In this way, Cazanat 40mg Tablet stops the body’s production, spread and growth of cancerous cells.
Directions For Use
Storage
- Store in a cool and dry place away from sunlight
Side Effects Of Cazanat 40mg Tablet
- Nausea
- Vomiting
- Diarrhoea
- Loss of appetite
- Increased blood pressure
- Tiredness
- Chest pain
- Dizziness
- Weakness
- Difficulty speaking
- Muscle pain
- Cough
- Shortness of breath
Precautions And Warning
To treat your condition effectually, continue taking Cazanat 40mg Tablet for the period that your doctor has prescribed. Caution should be exercised if you have/had liver or kidney disease, any planned surgery, heart disease, blood or bleeding disorders, open/healing of wound, or gastrointestinal disorders. Inform your doctor if you are pregnant or are planning to become pregnant before starting the treatment, as this medicine is known to cause embryo-fetal toxicity. Cazanat 40mg Tablet may cause hypertension, thrombotic events, hemorrhagic events, gastrointestinal perforation and fistula, Reversible Posterior Leukoencephalopathy Syndrome (RPLS), hepatotoxicity, severe diarrhoea, Osteonecrosis of the jaw (ONJ), Palmar-Plantar Erythrodysesthesia (PPE), adrenal insufficiency, impaired wound healing, and proteinuria in some patients. Hence, inform your doctor about your complete medication and medical history before taking Cazanat 40mg Tablet. Breastfeeding should be discontinued in nursing mothers during the treatment as it passes into breast milk and may cause a possible risk to the infant. Avoid driving and operating machines, as this medicine may cause dizziness. This medicine is not recommended for use in children below 18 years of age as the safety and efficacy are not established.
Interactions
Drug Interactions: Cazanat 40mg Tablet may have interaction with strong CYP3A4 inhibitors (clarithromycin, diltiazem, erythromycin, itraconazole, ketoconazole, ritonavir), strong CYP3A4 inducers (carbamazepine, rifampicin, phenytoin, phenobarbitone, dexamethasone).
Food Interactions: Avoid alcohol consumption and smoking.
Disease Interactions: Tell your doctor if you have liver or kidney disease, heart problems, GI perforation, thyroid dysfunction, or thromboembolism before starting the treatment.
Drug Interactions
- Clarithromycin
- Ritonavir
- Itraconazole
- Ketoconazole
- Diltiazem
- Erythromycin
- Carbamazepine
- Phenytoin
- Phenobarbital
- Rifampicin
Safety Advice
Alcohol
Avoid consumption of alcohol while on treatment with Cazanat 40mg Tablet as it may cause serious side effects.
Pregnancy
Cazanat 40mg Tablet is not recommended for use in pregnancy as it may cause embryo-fetal toxicity and harm your foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before taking Cazanat 40mg Tablet. You should not become pregnant while you are taking Cazanat 40mg Tablet for at least four months from the last dose of Cazanat 40mg Tablet. Using effective birth control methods while on treatment is suggested.
Breast Feeding
Cazanat 40mg Tablet should not be taken if you are breastfeeding as it passes into breast milk and may harm your infant. Avoid nursing your child while on treatment with this medicine and for at least four months from the last dose of medicine.
Driving
In some cases, Cazanat 40mg Tablet may cause dizziness and visual problems. As a result, do not drive, operate machinery, or engage in any activity that requires clear vision until you are satisfied you can drive while on Cazanat 40mg Tablet therapy.
Liver
If you have a pre-existing or a history of liver problems, tell your doctor before taking this medicine. Cazanat 40mg Tablet is known to cause hepatotoxicity when taken in combination with nivolumab. Hence, this medicine should be taken cautiously in patients with moderate liver impairment. Your doctor may suggest tests to monitor your liver function while on treatment with this medicine.
Kidney
If you have a pre-existing or a history of kidney diseases, inform your doctor before taking Cazanat 40mg Tablet. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.
Children
Cazanat 40mg Tablet is not recommended for use in children as the safety and efficacy are not established.
Diet & Lifestyle Advise
- Physical activity helps strengthen muscles, reduces fatigue, helps in weight loss, and gives strength. Gentle activities like 20-30 minutes of walking or swimming would be helpful.
- Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
- Getting adequate sleep as resting helps improve your health and mental ability and improves attention.
- De-stress yourself by meditating, reading books, taking a warm bubble bath, or listening to soothing music.
- Eat food rich in antioxidants such as berries, spinach, etc.
- Foods containing fibre help in better digestion. These include beans, peas, lentils, whole grains, nuts, and seeds.
- Avoid smoking and alcohol consumption.
- Maintain a healthy weight.
Special Advise
- Your doctor may suggest periodic liver function tests, kidney function tests, and urine tests to monitor the function of the liver kidney and the presence of protein in urine due to the use of Cazanat 40mg Tablet.
- Seek medical attention immediately if you have swelling in your lower legs, fast heartbeats, or trouble breathing, as it may be a sign of a heart problem.
- It is advised to use effective contraceptive methods while using Cazanat 40mg Tablet to prevent pregnancy.
