About Lynparza 150mg Tablet
Lynparza 150mg Tablet belongs to a group of medicines known as ‘anti-cancer’ drugs used to treat various cancers, including Ovarian, breast, pancreatic, and prostate. Cancer is a condition where cells in a specific body part grow and reproduce uncontrollably. The cancerous cells can attack and destroy surrounding healthy tissue, including organs.
Lynparza 150mg Tablet contains Olaparib, a targeted drug called a PARP inhibitor. PARP (polyadenosine 5’-diphosphoribose polymerase) is a protein that helps damaged cells repair themselves. Olaparib stops PARP working. Some cancer cells rely on PARP to keep their DNA healthy. So, the cancer cells die when Olaparib stops PARP from repairing DNA damage.
Use this medicine as directed by your doctor. You may sometimes experience shortness of breath (dyspnoea), feeling very tired, pale skin or fast heartbeat, anaemia, feeling sick (nausea), being sick (vomiting), indigestion or heartburn (dyspepsia), loss of appetite, headache, changes in taste of foods (dysgeusia), feeling dizzy, cough and diarrhoea. Most of these side effects may gradually resolve over time. However, if the side effects persist or worsen, consult your doctor.
To treat your condition effectually, continue taking Lynparza 150mg Tablet for as long as your doctor has prescribed. Do not stop using the Lynparza 150mg Tablet midway. Talk to your doctor before taking Lynparza 150mg Tablet if you have severe allergic reactions to Lynparza 150mg Tablet or other medicines or suffer from severe infections, renal dysfunction, hepatic disorders and blood cell counts are too low. Avoid taking Lynparza 150mg Tablet if you are pregnant or breastfeeding because this Lynparza 150mg Tablet can cause harmful effects on the unborn baby. Both women and men using this Lynparza 150mg Tablet should use birth control to avoid pregnancy. While on Lynparza 150mg Tablet treatment, you should avoid eating grapefruit, Seville oranges or consuming grapefruit juice since it can affect how the medicine works.
Uses Of Lynparza 150mg Tablet
- Cancer (Ovarian cancer, breast cancer, pancreatic cancer, and prostate cancer)
Medicinal Benefits
Lynparza 150mg Tablet contains Olaparib, a targeted drug called a PARP inhibitor. PARP is a protein that helps damaged cells to repair themselves. Olaparib stops PARP working. Some cancer cells rely on PARP to keep their DNA healthy. So, the cancer cells die when Olaparib stops PARP from repairing DNA damage. Thus, it treats various cancers, including Ovarian, breast, pancreatic, and prostate. It can be used alone or with other chemotherapy drugs, depending on your type of cancer.
Directions For Use
Storage
- Store in a cool and dry place away from sunlight
Side Effects Of Lynparza 150mg Tablet
- Feeling sick (nausea)
- Being sick (vomiting)
- Feeling tired or weak (fatigue)
- Feeling very tired
- Indigestion or heartburn (dyspepsia)
- Loss of appetite
- Headache
- Changes in the taste of foods (dysgeusia)
- Feeling dizzy
- Cough
- Shortness of breath (dyspnoea)
- Diarrhoea
- Low white blood cell count (leukopenia or neutropenia)
- Rash
- Sore mouth (stomatitis)
- Upper abdominal pain (pain in the stomach area under the ribs)
- Blood clot in a deep vein, usually in the leg (venous thrombosis)
Precautions And Warning
Always take this medicine exactly as your doctor or healthcare professional has told you. To treat your condition effectually, continue taking Lynparza 150mg Tablet for as long as your doctor has prescribed. Do not stop Lynparza 150mg Tablet midway. Talk to your doctor before taking Lynparza 150mg Tablet if you have severe allergic reactions to Lynparza 150mg Tablet or other medicines or suffer from any medical illness. Avoid taking Lynparza 150mg Tablet if you are pregnant or breastfeeding because this Lynparza 150mg Tablet can cause harmful effects on the unborn baby. Both women and men using this Lynparza 150mg Tablet should use birth control to avoid pregnancy. Do not start Lynparza 150mg Tablet unless patients have recovered from haematological damage induced by previous chemotherapy (Grade 1). Check full blood count for cytopenia at baseline and monthly afterwards for clinically significant changes during treatment. For persistent haematological toxicity, discontinue Lynparza 150mg Tablet and monitor blood count weekly until recovery. Do not receive any immunization or vaccination without your doctor’s approval while taking the Lynparza 150mg Tablet.
Interactions
Drug Interactions: Lynparza 150mg Tablet interacts with medicines used in the treatment of HIV (e.g. amprenavir, darunavir), a medication used to prevent chemotherapy-induced nausea and vomiting (e.g. aprepitant), vaccinations (e.g. BCG, Dengue vaccine, mumps virus vaccine), Antibacterial drugs (e.g. ciprofloxacin), and anti-fungal medications (e.g. fluconazole, itraconazole).
Food Interactions: Do not drink Grapefruit juice, Seville oranges and Alcoholic beverages while treated with Lynparza 150mg Tablet. It can affect the way the medicine works.
Disease Interactions: Inform your doctor before taking the Lynparza 150mg Tablet if you suffer from illness. It requires close monitoring if you suffer from Infections (bacterial/fungal/protozoal/viral), severe renal or hepatic dysfunctions and low blood count.
Drug Interactions
- Amprenavir
- Darunavir
- Aprepitant
- Bcg Vaccine
- Dengue Vaccine
- Mumps (Live Attenuated)
- Ciprofloxacin
- Fluconazole
- Itraconazole
Safety Advice
Alcohol
Avoid alcohol consumption while on treatment with Lynparza 150mg Tablet.
Pregnancy
Lynparza 150mg Tablet should not be used during pregnancy because it can harm your fetus (newborn baby). Both women of childbearing potential and men must use an effective contraception method while taking Lynparza 150mg Tablet and at least for six months later treatment. Your doctor will weigh the benefits and risks before prescribing this medicine.
Breast Feeding
Do not breastfeed during this treatment because the medicine may pass into your milk. Doctors normally advise against breastfeeding throughout this treatment and for one month after the final medication is taken.
Driving
Lynparza 150mg Tablet may affect your reactions and your ability to drive. Do not drive and/or operate machines that require your alertness.
Liver
In patients with mild or moderate liver impairment, there is no need to alter the initial dose. There is no information available on patients with severe liver impairment.
Kidney
In patients with mild or moderate kidney impairment, there is no need to alter the initial dose. There is no information available on patients with severe kidney impairment.
Children
The safety and effectiveness of Lynparza 150mg Tablet in pediatric patients have not been established.
Diet & Lifestyle Advise
- De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
- Performing yoga may also help in improving both physical and mental health.
- Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
- Eat a healthy diet and exercise regularly to maintain proper weight.
- Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs.
- Get optimal sleep; rest well.
- Avoid smoking and alcohol consumption.
- Avoid fast, fried, processed meats, refined carbs and added sugars.
Special Advise
- Pregnancy testing is recommended for females of reproductive potential prior to initiating treatment with Lynparza 150mg Tablet.
- Lynparza 150mg Tablet should be taken under strict medical supervision. The doctor will regularly monitor your condition while taking Lynparza 150mg Tablet.
- Monitor complete blood count for cytopenia at baseline and monthly for clinically significant changes during treatment.
- Your doctor may get routine blood tests done to monitor your liver function, electrolyte levels, and blood cell count in your blood.
- Peripheral blood counts should be frequently monitored during Lynparza 150mg Tablet treatment and, when appropriate, until recovery is achieved.
- Do not donate sperm during treatment with Lynparza 150mg Tablet for three months after your last dose.
